Chlorophyll b 

Chlorophyll b is an orally active tetrapyrrole derivative and pigment. Chlorophyll b can be obtained from photosynthetic organisms such as plants and algae. Chlorophyll b acts as a hydrogen donor and increases Glutathione levels. Chlorophyll b has antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. Chlorophyll b reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress. Chlorophyll b is mainly used in the study of plant photosynthesis mechanism^[1][2][3].

Chlorophyll b can serve as the major pigment in functional photosystem II complexes of cyanobacteria when introduced into a photosystem I-less strain of Synechocystis sp. PCC 6803 along with lhcb encoding light-harvesting complex (LHC)II from pea^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorophyll b (0.2-0.5 mg/kg; gavage; daily; 13 days) reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress in mice^[2].
Chlorophyll b (0.5 mg/kg; gavage; daily; 13 days) combined with lutein shows antigenotoxic and antimutagenic effects as well as prevents Cisplatin-induced GSH depletion in peripheral blood cells in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

908.48

C₅₅H₇₁MgN₄O₆⁺

519-62-0

Solid

Green to dark green

C=CC1=C(C)C2=CC3=NC(=C4[C@H](C(=O)C5=C(C)C(=CC6=C(CC)C(=CO)C(=N6)C=C1[N-]2)N=C54)C(=O)OC)[C@@H](CCC(=O)OC/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@@H]3C.[Mg+2]

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Xu H, et al. Chlorophyll b can serve as the major pigment in functional photosystem II complexes of cyanobacteria. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14168-73.  [Content Brief]

  [2]. Serpeloni JM, et al. An evaluation, using the comet assay and the micronucleus test, of the antigenotoxic effects of chlorophyll b in mice. Mutat Res. 2011 Oct 9;725(1-2):50-6.  [Content Brief]

  [3]. Serpeloni JM, et al. Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo. Hum Exp Toxicol. 2013 Aug;32(8):828-36.  [Content Brief]