2. GPCR/G Protein Neuronal Signaling Autophagy Metabolic Enzyme/Protease
  3. Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor
  4. Chlorpromazine (hydrochloride) (Standard)

Chlorpromazine (hydrochloride) (Standard) 

Cat. No.: HY-B0407AR Purity: ≥98%
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Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.

For research use only. We do not sell to patients.

Chlorpromazine (hydrochloride) (Standard) Chemical Structure

Chlorpromazine (hydrochloride) (Standard) Chemical Structure

CAS No. : 69-09-0

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Description

Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis.

Molecular Weight

355.33

Formula

C17H20Cl2N2S
CAS No.
SMILES

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=C(Cl)C=C13.Cl
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Chlorpromazine (hydrochloride) (Standard) Related Classifications

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Keywords:

Chlorpromazine (hydrochloride) (Standard)69-09-0Dopamine ReceptorAutophagyCytochrome P4505-HT ReceptorCYPsSerotonin Receptor5-hydroxytryptamine ReceptoraLQTSU-87MG glioma cellsBone marrow cellscancerschizophreniaCcOtumour immune escapeanalgesiccardiac arrhythmicInhibitorinhibitorinhibit

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