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CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy.

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CHNQD-01255 Chemical Structure

CHNQD-01255 Chemical Structure

CAS No. : 2756173-91-6

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Description

CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy[1].

In Vitro

CHNQD-01255 (0-1 μM approximately, 72 h) inhibits HepG2 and BEL-7402 cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHNQD-01255 Related Antibodies

Cell Proliferation AssayCHNQD-01255 (0-1 μM approximately, 72 h) inhibits HepG2 and BEL-7402 cell proliferation[1].

Cell Line: HepG2, BEL-7402 cell
Concentration: 0-1 μM approximately
Incubation Time: 72 h
Result: Inhibited cell proliferation with an IC50 value of 0.1 μM (HepG2) and 0.07 μM (BEL-7402).
In Vivo

CHNQD-01255 (5- 45 mg/kg, p.o.) inhibits tumor growth in HepG2 tumor-bearing xenograft mice[1].
CHNQD-01255 exhibits a high safety profile with MTD values exceeding 750 and 100 mg/kg for p.o. and i.p. administrations in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HepG2 tumor-bearing xenograft mice[1]
Dosage: 5, 15, and 45 mg/kg
Administration: Oral adminstration (p.o.), every day for 21 consecutive days.
Result: Resulted in dramatically delayed tumor progression, with a tumor growth inhibition rate (TGI %) value of 61.0% at 45 mg/kg.
Animal Model: HepG2 tumor-bearing xenograft mice[1]
Dosage: 1 and 9 mg/kg
Administration: Intraperitoneal injection (i.p.), every day for 21 consecutive days.
Result: Inhibited the tumor growth with the TGI values of 36.6 and 48.3%, respectively.
Animal Model: Mice (Pharmacokinetic assay)[1]
Dosage: 45 mg/kg p.o., 10 mg/kg i.v.
Administration: Oral adminstration (p.o.) or intravenous injection (i.v.)
Result: Pharmacokinetic profile of CHNQD-01255.
dose (mg/kg) T1/2 (h) Cmax (ng/mL) Cl (mL/h/kg) F (%)
45 (p.o.) 7.35 20.26 598245.37 2.26
10 (i.v.) 2060.78
Molecular Weight

415.48

Formula

C23H29NO6
CAS No.
SMILES

O[C@H]1[C@@]2([H])[C@@](/C=C/CCC[C@@H](OC(/C=C/1)=O)C)([H])C[C@@H](C2)OC(OCC3=CN=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHNQD-01255 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-012552756173-91-6CHNQD01255CHNQD 01255OthersBrefeldin Ahepatocellular carcinomaHCCHepG2BEL-7402tumorInhibitorinhibitorinhibit

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