2. Apoptosis
  3. Apoptosis
  4. ChoKα inhibitor-3

ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC50 value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer.

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ChoKα inhibitor-3 Chemical Structure

ChoKα inhibitor-3 Chemical Structure

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ChoKα inhibitor-3 Related Antibodies

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Description

ChoKα inhibitor-3 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-3 can inhibit HChoK α1 with an IC50 value of 0.66 μM. ChoKα inhibitor-3 also can induce apoptosis. ChoKα inhibitor-3 can be used for the research of cancer[1].

IC50 & Target

IC50: 0.66 μM (HChoK α1); 0.53 μM (A549); 0.26 μM (HeLa); 3.0 μM (HT-29); 1.34 μM (MCF7)[1]
In Vitro

ChoKα inhibitor-3 (PL 48) has HChoK α1 inhibition activity with an IC50 value of 0.66 μM[1].
ChoKα inhibitor-3 (1.46 μM; 72 h) can inhibit cell proliferation for A549, HeLa, HT-29 and MCF7 cells with IC50 values of 0.53 μM, 0.26 μM, 3.0 μM and1.34 μM, respectively[1].
ChoKα inhibitor-3 (1, 5 μM; 48, 72 h) induces apoptosis in cancer cells through the mitochondrial pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ChoKα inhibitor-3 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HT29, A549, HeLa, HT-29 and MCF7 cells
Concentration: 1.46 μM
Incubation Time: 72 h
Result: Had excellent growth inhibitory property.

Apoptosis Analysis[1]

Cell Line: A549 and HeLa cells
Concentration: 1, 5 μM
Incubation Time: 48, 72 h
Result: Induced a stronger mitochondrial depolarization in HeLa cells at early time-point treatment (24 h).

Western Blot Analysis[1]

Cell Line: HeLa and NHA cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly reduced the expression of the anti-apoptotic protein MCL-1.
Molecular Weight

1005.83

Formula

C50H54Br2Cl2N4S2
SMILES

C=CCCN(C1=CC=[N+](C2=C1C=CC(Cl)=C2)CC3=CC=C(C=C3)SCCSC4=CC=C(C=C4)C[N+]5=CC=C(C6=C5C=C(C=C6)Cl)N(CCC=C)CCC=C)CCC=C.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ChoKα inhibitor-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ChoKα inhibitor-3ChoKα inhibitor3ChoKα inhibitor 3Apoptosischoline kinaseHChoK α1cancerdithioethaneInhibitorinhibitorinhibit

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