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  3. Cilofexor tromethamine

Cilofexor tromethamine  (Synonyms: GS-9674 tromethamine)

Cat. No.: HY-109083A
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Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal farnesene oxide receptor agonist with activity in improving markers of cholestasis and liver injury. Cilofexor tromethamine was shown to be well tolerated in patients without cirrhosis and resulted in significant improvements in liver biochemical parameters and cholestatic markers. Cilofexor tromethamine offers a potential inhibitory option for the management of primary sclerosing cholangitis.

For research use only. We do not sell to patients.

Cilofexor tromethamine Chemical Structure

Cilofexor tromethamine Chemical Structure

CAS No. : 2253764-93-9

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Description

Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal farnesene oxide receptor agonist with activity in improving markers of cholestasis and liver injury. Cilofexor tromethamine was shown to be well tolerated in patients without cirrhosis and resulted in significant improvements in liver biochemical parameters and cholestatic markers. Cilofexor tromethamine offers a potential inhibitory option for the management of primary sclerosing cholangitis[1].

Molecular Weight

707.99

Formula

C32H33Cl3N4O8

CAS No.
SMILES

O=C(C1=CC(N2CC(C3=CC=C(C=C3Cl)OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)(C2)O)=NC=C1)O.OCC(CO)(CO)N

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Cilofexor tromethamine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cilofexor tromethamine
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HY-109083A
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