Cintirorgon sodium (Synonyms: LYC-55716 sodium)

Cat. No.: HY-104037A: FAQs
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Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

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Cintirorgon sodium Chemical Structure

CAS No. : 2055538-47-9

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Other In-stock Forms of Cintirorgon sodium:

Cintirorgon

Other Forms of Cintirorgon sodium:

Cintirorgon In-stock

7 Publications Citing Use of MCE Cintirorgon sodium

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RORγ RORα RORβ

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Description	Cintirorgon sodium is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon sodium (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival^[1]^[2].
Molecular Weight	625.51
Formula	C₂₇H₂₂F₆NNaO₆S
CAS No.	2055538-47-9
SMILES	O=C(O[Na])C(C)(C)C[C@@H]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Lycera Announces Initiation of Phase 1/2a Study ARGON of Immuno-Oncology Candidate LYC-55716 in Patients with Advanced Solid Tumors. Jan 04, 2017.

Cintirorgon sodium Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cintirorgon2055538-47-9LYC-55716LYC55716LYC 55716RORRAR-related orphan receptorInhibitorinhibitorinhibit

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Cintirorgon sodium (Synonyms: LYC-55716 sodium)

Other Forms of Cintirorgon sodium:

Cintirorgon sodium Related Antibodies

7 Publications Citing Use of MCE Cintirorgon sodium

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ROR Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review