Cipralisant (enantiomer) (Synonyms: GT-2331 (enantiomer))

Cat. No.: HY-106993B Purity: 96.38% ee.: 100%: FAQs
Data Sheet SDS COA Handling Instructions

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Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H₃ receptor antagonist (rat K_i=0.47 nM). Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Cipralisant (enantiomer) Chemical Structure

CAS No. : 223420-11-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 714	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 714	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 4480	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 7170	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Cipralisant (enantiomer):

Cipralisant Get quote
Cipralisant maleate Get quote

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

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Description

Cipralisant (GT-2331) enantiomer is the enantiomer of Cipralisant (HY-106993), Cipralisant is an orally active, potent, selective, and high affinity histamine H₃ receptor antagonist (rat K_i=0.47 nM)^[1]^[2]^[3]^[4]^[5]. Cipralisant (enantiomer) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

216.32

Formula

C₁₄H₂₀N₂

CAS No.

223420-11-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)(C)CCC#C[C@@H]1[C@@H](C2=CN=CN2)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (462.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6228 mL	23.1139 mL	46.2278 mL
5 mM	0.9246 mL	4.6228 mL	9.2456 mL
10 mM	0.4623 mL	2.3114 mL	4.6228 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.38% ee.: 100%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (242 KB) HNMR (229 KB) NP-HPLC (152 KB) LCMS (132 KB)

Handling Instructions (2659 KB)

References

[1]. Liu H, et al. An efficient multigram synthesis of the potent histamine H3 antagonist GT-2331 and the reassessment of the absolute configuration. J Org Chem. 2004 Jan 9;69(1):192-4. [Content Brief]

[2]. Raddatz R, et al. Histamine H3 antagonists for treatment of cognitive deficits in CNS diseases. Curr Top Med Chem. 2010;10(2):153-69. [Content Brief]

[3]. Fox GB, et al. Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup. Behav Brain Res. 2002 Apr 1;131(1-2):151-61. [Content Brief]

[4]. Ito S, et al. Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor. Eur J Pharmacol. 2006 Jan 4;529(1-3):40-6. [Content Brief]

[5]. Tedford CE, et al. High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models. Eur J Pharmacol. 1998 Jun 26;351(3):307-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6228 mL	23.1139 mL	46.2278 mL	115.5695 mL
	5 mM	0.9246 mL	4.6228 mL	9.2456 mL	23.1139 mL
	10 mM	0.4623 mL	2.3114 mL	4.6228 mL	11.5570 mL
	15 mM	0.3082 mL	1.5409 mL	3.0819 mL	7.7046 mL
	20 mM	0.2311 mL	1.1557 mL	2.3114 mL	5.7785 mL
	25 mM	0.1849 mL	0.9246 mL	1.8491 mL	4.6228 mL
	30 mM	0.1541 mL	0.7705 mL	1.5409 mL	3.8523 mL
	40 mM	0.1156 mL	0.5778 mL	1.1557 mL	2.8892 mL
	50 mM	0.0925 mL	0.4623 mL	0.9246 mL	2.3114 mL
	60 mM	0.0770 mL	0.3852 mL	0.7705 mL	1.9262 mL
	80 mM	0.0578 mL	0.2889 mL	0.5778 mL	1.4446 mL
	100 mM	0.0462 mL	0.2311 mL	0.4623 mL	1.1557 mL

Cipralisant (enantiomer) Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cipralisant (enantiomer)223420-11-9GT-2331 (enantiomer)Histamine Receptorenantiomeroral activityhigh affinityInhibitorinhibitorinhibit

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Cipralisant (enantiomer) (Synonyms: GT-2331 (enantiomer))

Customer Review

Other Forms of Cipralisant (enantiomer):

Cipralisant (enantiomer) Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

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Dilution Calculator

Complete Stock Solution Preparation Table

Cipralisant (enantiomer) Related Classifications

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