2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. cis-3,4',5-Trimethoxy-3'-hydroxystilbene

cis-3,4',5-Trimethoxy-3'-hydroxystilbene is a stilbene. cis-3,4',5-Trimethoxy-3'-hydroxystilbene induces cytochrome c release to the cytoplasm. cis-3,4',5-Trimethoxy-3'-hydroxystilbene-induced apoptosis is associated with mitochondrial release of cytochrome c. cis-3,4',5-Trimethoxy-3'-hydroxystilbene also suppresses tubulin polymerization. cis-3,4',5-Trimethoxy-3'-hydroxystilbene can be used for leukemic research.

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cis-3,4',5-Trimethoxy-3'-hydroxystilbene Chemical Structure

cis-3,4',5-Trimethoxy-3'-hydroxystilbene Chemical Structure

CAS No. : 586410-08-4

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cis-3,4',5-Trimethoxy-3'-hydroxystilbene Related Antibodies

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Description

cis-3,4',5-Trimethoxy-3'-hydroxystilbene is a stilbene. cis-3,4',5-Trimethoxy-3'-hydroxystilbene induces cytochrome c release to the cytoplasm. cis-3,4',5-Trimethoxy-3'-hydroxystilbene-induced apoptosis is associated with mitochondrial release of cytochrome c. cis-3,4',5-Trimethoxy-3'-hydroxystilbene also suppresses tubulin polymerization. cis-3,4',5-Trimethoxy-3'-hydroxystilbene can be used for leukemic research[1].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
30 nM
Compound: 1b
Induction of apoptosis in human HL60 cells by flow cytometry
Induction of apoptosis in human HL60 cells by flow cytometry
[PMID: 19117761]
SNU-423 IC50
15 nM
Compound: 1b
Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
Cytotoxicity against human SNU423 cells after 48 hrs by alamar blue assay
[PMID: 19117761]
In Vitro

cis-3,4',5-Trimethoxy-3'-hydroxystilbene (10-500 nM) 消除 HL60 细胞的集落形成能力[1]。
cis-3,4',5-Trimethoxy-3'-hydroxystilbene (10-500 nM) 会导致 HL60 细胞出现剂量依赖性凋亡，但不影响骨髓祖细胞[1]。
cis-3,4',5-Trimethoxy-3'-hydroxystilbene (0-100 μM) 以剂量依赖性方式抑制微管蛋白聚合[1]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-3,4',5-Trimethoxy-3'-hydroxystilbene Related Antibodies
Molecular Weight

286.32

Formula

C17H18O4
CAS No.
SMILES

OC(C=C1/C=C\C2=CC(OC)=CC(OC)=C2)=C(C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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cis-3,4',5-Trimethoxy-3'-hydroxystilbene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-3,4',5-Trimethoxy-3'-hydroxystilbene586410-08-4Microtubule/TubulinApoptosisHL60 cellsbone marrow progenitor cellstubulin polymerizationleukemicInhibitorinhibitorinhibit

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