2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. cis-4-Hydroxy-L-proline hydrochloride

cis-4-Hydroxy-L-proline hydrochloride 

Cat. No.: HY-W019213 Purity: ≥97.0%
SDS COA Handling Instructions

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cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

cis-4-Hydroxy-L-proline hydrochloride Chemical Structure

cis-4-Hydroxy-L-proline hydrochloride Chemical Structure

CAS No. : 441067-49-8

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Other Forms of cis-4-Hydroxy-L-proline hydrochloride:

cis-4-Hydroxy-L-proline hydrochloride Related Antibodies

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Description

cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cis-4-Hydroxy-L-proline hydrochloride Related Antibodies
Molecular Weight

167.59

Formula

C5H10ClNO3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[H]Cl.O=C(O)[C@H]1NC[C@@H](O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

SDS (394 KB)

COA (248 KB) HNMR (130 KB)

Handling Instructions (2659 KB)
References
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cis-4-Hydroxy-L-proline hydrochloride Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-4-Hydroxy-L-proline441067-49-8ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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