2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. cis-ACBD

cis-ACBD  (Synonyms: cis-1-Aminocyclobutane-1,3-dicarboxylic acid)

Cat. No.: HY-100616 Purity: ≥98.0%
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cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate.

For research use only. We do not sell to patients.

cis-ACBD Chemical Structure

cis-ACBD Chemical Structure

CAS No. : 73550-55-7

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2 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of cis-ACBD:

cis-ACBD Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

cis-ACBD is a potent and selective inhibitor of the high-affinity, Na+-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate[1][2].

Molecular Weight

159.14

Formula

C6H9NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@]1(C[C@@H](C1)C(O)=O)N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (392.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2838 mL 31.4189 mL 62.8377 mL
5 mM 1.2568 mL 6.2838 mL 12.5676 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.2838 mL 31.4189 mL 62.8378 mL 157.0944 mL
5 mM 1.2568 mL 6.2838 mL 12.5676 mL 31.4189 mL
10 mM 0.6284 mL 3.1419 mL 6.2838 mL 15.7094 mL
15 mM 0.4189 mL 2.0946 mL 4.1892 mL 10.4730 mL
20 mM 0.3142 mL 1.5709 mL 3.1419 mL 7.8547 mL
25 mM 0.2514 mL 1.2568 mL 2.5135 mL 6.2838 mL
30 mM 0.2095 mL 1.0473 mL 2.0946 mL 5.2365 mL
40 mM 0.1571 mL 0.7855 mL 1.5709 mL 3.9274 mL
50 mM 0.1257 mL 0.6284 mL 1.2568 mL 3.1419 mL
60 mM 0.1047 mL 0.5236 mL 1.0473 mL 2.6182 mL
80 mM 0.0785 mL 0.3927 mL 0.7855 mL 1.9637 mL
100 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5709 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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cis-ACBD Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cis-ACBD73550-55-7cis-1-Aminocyclobutane-1,3-dicarboxylic acidSodium ChannelNa channelsNa+ channelsaspartateglutamateNa+sodium ionsglutamate uptakeInhibitorinhibitorinhibit

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