(6S,12aR)-Tadalafil (Synonyms: Tadalafil EP Impurity C; (6S,12aR)-IC-351)

Cat. No.: HY-90009D: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC₅₀ value of 5 nM and has blood pressure lowering activity.

For research use only. We do not sell to patients.

(6S,12aR)-Tadalafil Chemical Structure

CAS No. : 171596-28-4

Size	Price	Stock
1 mg	USD 420	Ask For Quote & Lead Time
5 mg	USD 920	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of (6S,12aR)-Tadalafil:

Nortadalafil In-stock
Tadalafil In-stock
12-epi-Tadalafil Get quote
ent-Tadalafil Get quote

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
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Description

(6S,12aR)-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC₅₀ value of 5 nM and has blood pressure lowering activity^[1].

Molecular Weight

389.40

Formula

C₂₂H₁₉N₃O₄

CAS No.

171596-28-4

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]1([H])CC2=C([C@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.34%

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Data Sheet (275 KB) SDS (393 KB)

COA (261 KB) HNMR (138 KB) CNMR (159 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

References

[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42. [Content Brief]

(6S,12aR)-Tadalafil Related Classifications

Metabolic Disease Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(6S,12aR)-Tadalafil171596-28-4Tadalafil EP Impurity C (6S,12aR)-IC-351Phosphodiesterase (PDE)PDE5 inhibitorInhibitorinhibitorinhibit

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