1. Apoptosis
  2. RIP kinase TNF Receptor Apoptosis
  3. Cl-Necrostatin-1

Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases.

For research use only. We do not sell to patients.

Cl-Necrostatin-1 Chemical Structure

Cl-Necrostatin-1 Chemical Structure

CAS No. : 862377-51-3

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Description

Cl-Necrostatin-1 is a RIPK1 inhibitor. Cl-Necrostatin-1 can also inhibit TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 can also reduce infarct size in a mouse model of middle cerebral artery occlusion (MCAO). Cl-Necrostatin-1 is used for research in cardiovascular and cerebrovascular diseases[1][2][3].

Molecular Weight

293.77

Formula

C13H12ClN3OS

CAS No.
SMILES

O=C1N(C)C(NC1CC2=CNC3=C2C=CC=C3Cl)=S

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Purity & Documentation
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Cl-Necrostatin-1 Related Classifications

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Cl-Necrostatin-1
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