2. PROTAC
  3. PROTAC Linkers
  4. Cl-PEG6-acid

Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Cl-PEG6-acid Chemical Structure

Cl-PEG6-acid Chemical Structure

CAS No. : 2365309-92-6

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100 mg USD 113 In-stock
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Based on 1 publication(s) in Google Scholar

Cl-PEG6-acid Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cl-PEG6-acid Related Antibodies
Molecular Weight

358.81

Formula

C14H27ClO8
CAS No.
Appearance

Liquid (Density: 1.181±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

OC(COCCOCCOCCOCCOCCOCCCl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (278.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7870 mL 13.9350 mL 27.8699 mL
5 mM 0.5574 mL 2.7870 mL 5.5740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7870 mL 13.9350 mL 27.8699 mL 69.6748 mL
5 mM 0.5574 mL 2.7870 mL 5.5740 mL 13.9350 mL
10 mM 0.2787 mL 1.3935 mL 2.7870 mL 6.9675 mL
15 mM 0.1858 mL 0.9290 mL 1.8580 mL 4.6450 mL
20 mM 0.1393 mL 0.6967 mL 1.3935 mL 3.4837 mL
25 mM 0.1115 mL 0.5574 mL 1.1148 mL 2.7870 mL
30 mM 0.0929 mL 0.4645 mL 0.9290 mL 2.3225 mL
40 mM 0.0697 mL 0.3484 mL 0.6967 mL 1.7419 mL
50 mM 0.0557 mL 0.2787 mL 0.5574 mL 1.3935 mL
60 mM 0.0464 mL 0.2322 mL 0.4645 mL 1.1612 mL
80 mM 0.0348 mL 0.1742 mL 0.3484 mL 0.8709 mL
100 mM 0.0279 mL 0.1393 mL 0.2787 mL 0.6967 mL
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Cl-PEG6-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cl-PEG6-acid2365309-92-6PROTAC LinkersInhibitorinhibitorinhibit

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