CL67

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CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer.

For research use only. We do not sell to patients.

CL67 Chemical Structure

CAS No. : 1401242-86-1

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HIF-1α HIF

Biological Activity
Purity & Documentation
References
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Description

CL67 is a potent hypoxia-inducible factor (HIF) pathway inhibitor. CL67 interferes G-quadruplex structures within promoter sequences. CL67 can be used in research of renal cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	2.3 μM Compound: 13, CL67	Antiproliferative activity against human 786-O cells after 96 hrs by SRB assay Antiproliferative activity against human 786-O cells after 96 hrs by SRB assay	[PMID: 22889802]
A498	IC₅₀	2.5 μM Compound: 13, CL67	Antiproliferative activity against human A498 cells after 96 hrs by SRB assay Antiproliferative activity against human A498 cells after 96 hrs by SRB assay	[PMID: 22889802]
A549	IC₅₀	60 μM Compound: 13, CL67	Antiproliferative activity against human A549 cells after 96 hrs by SRB assay Antiproliferative activity against human A549 cells after 96 hrs by SRB assay	[PMID: 22889802]
HOS	IC₅₀	2.4 μM Compound: 13, CL67	Antiproliferative activity against human HOS cells after 96 hrs by SRB assay Antiproliferative activity against human HOS cells after 96 hrs by SRB assay	[PMID: 22889802]
HOS-TE85	IC₅₀	3.2 μM Compound: 13, CL67	Antiproliferative activity against human MNNG-HOS cells after 96 hrs by SRB assay Antiproliferative activity against human MNNG-HOS cells after 96 hrs by SRB assay	[PMID: 22889802]
HPAC	IC₅₀	7.3 μM Compound: 13, CL67	Antiproliferative activity against human HPAC cells after 96 hrs by SRB assay Antiproliferative activity against human HPAC cells after 96 hrs by SRB assay	[PMID: 22889802]
MCF7	IC₅₀	63 μM Compound: 13, CL67	Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 96 hrs by SRB assay	[PMID: 22889802]
MG-63	IC₅₀	7.9 μM Compound: 13, CL67	Antiproliferative activity against human MG63 cells after 96 hrs by SRB assay Antiproliferative activity against human MG63 cells after 96 hrs by SRB assay	[PMID: 22889802]
MIA PaCa-2	IC₅₀	16.8 μM Compound: 13, CL67	Antiproliferative activity against human MIAPaCa2 cells after 96 hrs by SRB assay Antiproliferative activity against human MIAPaCa2 cells after 96 hrs by SRB assay	[PMID: 22889802]
OST	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human OST cells after 96 hrs by SRB assay Antiproliferative activity against human OST cells after 96 hrs by SRB assay	[PMID: 22889802]
PANC-1	IC₅₀	31 μM Compound: 13, CL67	Antiproliferative activity against human PANC1 cells after 96 hrs by SRB assay Antiproliferative activity against human PANC1 cells after 96 hrs by SRB assay	[PMID: 22889802]
PC-3	IC₅₀	8.05 μM Compound: 13, CL67	Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay Antiproliferative activity against human PC3 cells after 96 hrs by SRB assay	[PMID: 22889802]
RCC4	IC₅₀	1.3 μM Compound: 13, CL67	Antiproliferative activity against human RCC4 cells after 96 hrs by SRB assay Antiproliferative activity against human RCC4 cells after 96 hrs by SRB assay	[PMID: 22889802]
RCC4/VHL	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human RCC4/VHL cells after 96 hrs by SRB assay Antiproliferative activity against human RCC4/VHL cells after 96 hrs by SRB assay	[PMID: 22889802]
SAOS-2	IC₅₀	2.6 μM Compound: 13, CL67	Antiproliferative activity against human Saos2 cells after 96 hrs by SRB assay Antiproliferative activity against human Saos2 cells after 96 hrs by SRB assay	[PMID: 22889802]
TC-32	IC₅₀	0.9 μM Compound: 13, CL67	Antiproliferative activity against human TC32 cells after 96 hrs by SRB assay Antiproliferative activity against human TC32 cells after 96 hrs by SRB assay	[PMID: 22889802]
U2OS	IC₅₀	5.5 μM Compound: 13, CL67	Antiproliferative activity against human U2OS cells after 96 hrs by SRB assay Antiproliferative activity against human U2OS cells after 96 hrs by SRB assay	[PMID: 22889802]
WI-38	IC₅₀	91 μM Compound: 13, CL67	Cytotoxicity against human WI38 after 96 hrs by SRB assay Cytotoxicity against human WI38 after 96 hrs by SRB assay	[PMID: 22889802]

In Vitro

CL67 (RCC4 and RCC4VHL cells) inhibits HIF-1α protein in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

670.81

Formula

C₃₈H₄₂N₁₀O₂

CAS No.

1401242-86-1

SMILES

O=C(NC1=CC=CC(N2N=NC(C3=CC=C4C=CC(C5=CN(C6=CC(NC(CN(CC)CC)=O)=CC=C6)N=N5)=CC4=C3)=C2)=C1)CN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sarah JW, et, al. CL67: A novel G-quadruplex stabilising agent inhibits the HIF-1 pathway. Cancer Res (2011) 71 (8_Supplement):4506.

CL67 Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CL671401242-86-1CL 67CL-67HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHhypoxia-inducible factorG-quadruplex structurespromoter sequencesrenal cancerInhibitorinhibitorinhibit

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