2. Anti-infection
  3. Fungal Antibiotic
  4. Cladosporin

Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL.

For research use only. We do not sell to patients.

Cladosporin Chemical Structure

Cladosporin Chemical Structure

CAS No. : 35818-31-6

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500 μg In-stock
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Based on 1 publication(s) in Google Scholar

Cladosporin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cladosporin is a fungal metabolite produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin completely inhibits growth of severa dermatophytes on agar medium at a concentration of 75 μg/mL[1].

Cellular Effect
Cell Line Type Value Description References
BV-2 IC50
24 μM
Compound: 2
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in NO production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by Greiss assay
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in NO production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by Greiss assay
[PMID: 26651366]
BV-2 IC50
27 μM
Compound: 2
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in PGE2 production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by ELISA
Antiinflammatory activity in LPS-induced human BV2 cells assessed as reduction in PGE2 production pretreated for 30 mins followed by LPS stimulation measured for 24 hrs by ELISA
[PMID: 26651366]
Molecular Weight

292.33

Formula

C16H20O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=C(O)C=C(O)C=C2C[C@H](C[C@H]3CCC[C@H](C)O3)O1
Structure Classification
Initial Source

Cladosporium cladosporioides
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4208 mL 17.1040 mL 34.2079 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (251 KB)

COA (247 KB) HNMR (268 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4208 mL 17.1040 mL 34.2079 mL 85.5198 mL
5 mM 0.6842 mL 3.4208 mL 6.8416 mL 17.1040 mL
10 mM 0.3421 mL 1.7104 mL 3.4208 mL 8.5520 mL
15 mM 0.2281 mL 1.1403 mL 2.2805 mL 5.7013 mL
20 mM 0.1710 mL 0.8552 mL 1.7104 mL 4.2760 mL
25 mM 0.1368 mL 0.6842 mL 1.3683 mL 3.4208 mL
30 mM 0.1140 mL 0.5701 mL 1.1403 mL 2.8507 mL
40 mM 0.0855 mL 0.4276 mL 0.8552 mL 2.1380 mL
50 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.7104 mL
60 mM 0.0570 mL 0.2851 mL 0.5701 mL 1.4253 mL
80 mM 0.0428 mL 0.2138 mL 0.4276 mL 1.0690 mL
100 mM 0.0342 mL 0.1710 mL 0.3421 mL 0.8552 mL
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Cladosporin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cladosporin35818-31-6FungalAntibioticfungal metaboliteCladosporium cladosporioidInhibitorinhibitorinhibit

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