2. Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. ClpP Apoptosis Reactive Oxygen Species
  4. CLPP-2068

CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models.

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CLPP-2068 Chemical Structure

CLPP-2068 Chemical Structure

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CLPP-2068 Related Antibodies

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Description

CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models[1].

Molecular Weight

464.36

Formula

C23H22BrN5O
SMILES

O=C1NC(NCC2=CC=C(Br)C=C2)=NC3=C1CN([C@H](C)C3)CC4=CC(C#N)=CC=C4
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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CLPP-2068 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLPP-2068CLPP2068CLPP 2068ClpPApoptosisReactive Oxygen SpeciesCaseinolytic protease PDLBCLOCI-LY10NOD-SCID mouseorally activeInhibitorinhibitorinhibit

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