CLX-0921

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CLX-0921 is an orally active PPARγ agonist with an IC₅₀ of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.

For research use only. We do not sell to patients.

CLX-0921 Chemical Structure

CAS No. : 249886-47-3

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Description

CLX-0921 is an orally active PPARγ agonist with an IC₅₀ of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes^[1].

IC₅₀ & Target^[1]

PPARγ

1.54 μM (IC₅₀)

In Vitro

CLX-0921 (0.01 M, 0.1 M, 1.0 M, and 10 M) increases glucose uptake in 3T3-L1 adipocytes. CLX-0921 has potent antihyperglycemic activity with low adipogenic potential^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CLX-0921 (3.1-12.5 mg/kg; oral gavage; once daily; for 19 days) shows dose-dependent antihyperglycemic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL/KsJ-db/db and C57BL/6J-ob/ob mice (7-week-old)^[1]
Dosage:	3.1 mg/kg, 6.3 mg/kg, and 12.5 mg/kg
Administration:	Oral gavage; once daily; for 19 days
Result:	Showed dose-dependent antihyperglycemic activity.

Molecular Weight

519.57

Formula

C₂₈H₂₅NO₇S

CAS No.

249886-47-3

SMILES

O=C(OC)/C(C1=CC=C(OC2=CC=C(CC(SC(N3)=O)C3=O)C=C2)C=C1)=C/C4=CC(OC)=CC(OC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Debendranath Dey, et al. A novel peroxisome proliferator-activated gamma (PPAR gamma) agonist, CLX-0921, has potent antihyperglycemic activity with low adipogenic potential. Metabolism. 2003 Aug;52(8):1012-8. [Content Brief]

CLX-0921 Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLX-0921249886-47-3CLX0921CLX 0921PPARPeroxisome proliferator-activated receptorsPPARγ agonistorally activeantihyperglycemic activitytype 2 diabetesInhibitorinhibitorinhibit

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