CM-444

Cat. No.: HY-163803: FAQs
Data Sheet Handling Instructions

Molarity Calculator

CM-444 is inhibitor for HDAC (IC₅₀ is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC₅₀ is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models.

For research use only. We do not sell to patients.

CM-444 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

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•Related Small Molecules:

•Related Proteins:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All DNA Methyltransferase Isoform Specific Products:

View All Isoforms

DNA Methyltransferase DNMT1 DNMT3 MGMT

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

HDAC1

6.55 nM (IC₅₀)

HDAC10

15 nM (IC₅₀)

HDAC3

18 nM (IC₅₀)

HDAC2

51 nM (IC₅₀)

HDAC5

59 nM (IC₅₀)

HDAC4

62 nM (IC₅₀)

HDAC8

83 nM (IC₅₀)

HDAC9

90 nM (IC₅₀)

HDAC7

120 nM (IC₅₀)

HDAC6

531 nM (IC₅₀)

HDAC11

567.5 nM (IC₅₀)

DNMT3A

1.8 μM (IC₅₀)

DNMT1

2.2 μM (IC₅₀)

DNMT3B

2.3 μM (IC₅₀)

Molecular Weight

518.56

Formula

C₂₇H₃₀N₆O₅

SMILES

O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. San José-Enériz E, et al., Epigenetic-based differentiation therapy for Acute Myeloid Leukemia. Nat Commun. 2024 Jul 2;15(1):5570. [Content Brief]

CM-444 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM-444CM444CM 444HDACDNA MethyltransferaseHistone deacetylasesDNMTsDNA MTasesAMLacute myeloid leukemiaHL-60ML-2MV4-11MOLM-13anti-leukemicBALB/c mouseInhibitorinhibitorinhibit

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