2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. cMCoFx1

cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

cMCoFx1 Chemical Structure

cMCoFx1 Chemical Structure

CAS No. : 2853605-24-8

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cMCoFx1 Related Antibodies

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Description

cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic[1].

IC50 & Target

Ki: 370 pM (FXIIa)[1]
Molecular Weight

3612.12

Formula

C146H232N52O44S6
CAS No.
Sequence

cyclo(Asp-Gly-Gly-Ile-Cys-Pro-Arg-Ile-Gly-Arg-Leu-Cys-Arg-Arg-Asp-Ser-Asp-Cys-Pro-Gly-Ala-Cys-Ile-Cys-Arg-Ala-Thr-Arg-Phe-Cys-Gly-Ser-Gly-Tyr) (disulfide bridge: Cys2-Cys19; Cys4-Cys26; Cys10-Cys32)
Sequence Shortening

cyclo(ACICRATRFCGSGYDGGICPRIGRLCRRDSDCPG) (disulfide bridge: Cys2-Cys19; Cys4-Cys26; Cys10-Cys32)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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cMCoFx1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cMCoFx12853605-24-8cMCoFx 1cMCoFx-1Factor XaFxaHUVECsInhibitorinhibitorinhibit

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