2. Anti-infection
  3. Antibiotic Bacterial
  4. Colistin

Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Colistin sulfate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Colistin Chemical Structure

Colistin Chemical Structure

CAS No. : 1066-17-7

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Colistin Related Antibodies

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Description

Colistin (Polymyxin E) is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

In Vivo

Colistin (Polymyxin E) (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[1]
Dosage: 16 mg/kg/day
Administration: 16 mg/kg/day, i.p.
Result: Detected apoptosis, necrosis PCNA staining in mice.
Clinical Trial
Molecular Weight

1169.50

Formula

C53H100N16O13 (for E1)
CAS No.
SMILES

[Colistin]
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Colistin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Colistin1066-17-7Polymyxin EAntibioticBacterialoralpolypeptide antibioticPseudomonas aeruginosaKlebsiella pneumoniaeAcinetobacter baumanniiGram-negative bacterianephrotoxicityinfectionInhibitorinhibitorinhibit

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