Communic acid (Synonyms: (+)-Communic acid)

Cat. No.: HY-N3612: FAQs
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Communic acid ((+)-Communic acid) is a natural compound isolated from the branches of Platycladus orientalis. Communic acid displays minimum inhibitory concentration of 31 μM and IC₅₀ of 15 μM against M. tuberculosis H37Ra.Communic acid exhibits protective effects against UVB-induced skin aging.

For research use only. We do not sell to patients.

Communic acid Chemical Structure

CAS No. : 2761-77-5

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Other Forms of Communic acid:

trans-Communic acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

15 μM (M. tuberculosis H37Ra) ^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 40 μM Compound: 15	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23691952]
HL-60	IC₅₀	> 40 μM Compound: 15	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23691952]
MCF7	IC₅₀	> 40 μM Compound: 15	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23691952]
SMMC-7721	IC₅₀	> 40 μM Compound: 15	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 23691952]
SW480	IC₅₀	> 40 μM Compound: 15	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23691952]

Molecular Weight

302.45

Formula

C₂₀H₃₀O₂

CAS No.

2761-77-5

SMILES

C[C@@]1([C@H]2C/C=C(C)/C=C)[C@](CCC2=C)([H])[C@](C)(CCC1)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Animals

Brazilian brown propolis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Samoylenko V, et al. Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. Phytother Res. 2008;22(12):1570-1576. [Content Brief]

[2]. Carpenter CD, et al. Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis. J Ethnopharmacol. 2012;143(2):695-700. [Content Brief]

[3]. Huh WB, et al. Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K. PLoS One. 2015;10(6):e0128365. Published 2015 Jun 11. [Content Brief]

Communic acid Related Classifications

Inflammation/Immunology Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Communic acid2761-77-5(+)-Communic acidAktBacterialMMPPKBProtein kinase BMatrix metalloproteinasesPlatycladus orientalisM. tuberculosis H37RaHaCaTUVB-induced skin agingInhibitorinhibitorinhibit

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