2. Academic Validation
  3. Diterpenoids from the twigs and leaves of Fokienia hodginsii

Diterpenoids from the twigs and leaves of Fokienia hodginsii

  • J Nat Prod. 2013 Jun 28;76(6):1032-8. doi: 10.1021/np400010c.
Xing-De Wu 1,  Juan He,  Xing-Yao Li,  Liao-Bin Dong,  Xun Gong,  Liu-Dong Song,  Yan Li,  Li-Yan Peng,  Qin-Shi Zhao
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
PMID: 23691952 DOI: 10.1021/np400010c
Abstract

Five new isopimarane Diterpenoids, fokihodgins A-E (1-5), four new labdane Diterpenoids, fokihodgins F-I (6-9), and one new icetexane diterpenoid, fokihodgin J (10), as well as 18 known Diterpenoids were isolated from Fokienia hodginsii. The structures of the new compounds were determined on the basis of their spectroscopic analysis, and the absolute configurations of 1 and 6 were established by X-ray crystallographic analysis. Compound 9 showed moderate cytotoxicity against HL-60 and SMMC-7721 cell lines, with IC50 values of 9.10 and 7.50 μM, respectively.

Figures