2. Immunology/Inflammation
  3. Complement System
  4. Complement C1s-IN-1

Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM.

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Complement C1s-IN-1 Chemical Structure

Complement C1s-IN-1 Chemical Structure

CAS No. : 3033831-40-9

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Complement C1s-IN-1 Related Antibodies

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Description

Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM[1].

IC50 & Target

IC50: 36 nM (C1s)[1]
In Vivo

Complement C1s-IN-1 (compound (R)-8) (10, 30, 100 mg/kg; p.o.) inhibits MAC formation induced by human serum and shows plasma exposure after oral administration in a dose-dependent manner[1].
Pharmacokinetic Parameters of Complement C1s-IN-1 in Male C57BL/6J mice[1].

Dosage (mg/kg) Cmax (ng/mL) Tmax (h) AUC(0-24h) (h* ng/mL) MRT (h)
10 1032.5±173.0 1.67±0.58 6017.8±390.4 4.31±0.23
30 2583.3±267.1 2.67±1.15 21928.6±1428.2 5.02±0.18
100 8895.9±1516.8 4.00±0.00 13934.1±36760.1 7.66±0.99
Male C57BL/6J mice, 10, 30, 100 mg/kg; p.o.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice[1]
Dosage: 10, 30, 100 mg/kg
Administration: P.o.
Result: Significantly inhibited MAC formation induced by human serum in a dose-dependent manner.
Molecular Weight

422.43

Formula

C22H20F2N6O
CAS No.
SMILES

NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Complement C1s-IN-1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Complement C1s-IN-13033831-40-9Complement Systemorally activecross the blood-brain barrierInhibitorinhibitorinhibit

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