2. GPCR/G Protein
  3. GHSR
  4. Cortistatin-8

Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals.

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Cortistatin-8 Chemical Structure

Cortistatin-8 Chemical Structure

CAS No. : 485803-62-1

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Cortistatin-8 Related Antibodies

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GHSR1a

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Description

Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1].

IC50 & Target[1]

GHSR1a

 

Molecular Weight

1009.25

Formula

C47H68N12O9S2
CAS No.
Sequence

Pro-Cys-Phe-{d-Trp}-Lys-Thr-Cys-Lys-NH2 (disulfide bridge: Cys2-Cys7)
Sequence Shortening

PCF-{d-Trp}-WKTCK-NH2 (disulfide bridge: Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cortistatin-8 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-8485803-62-1PCFWKTCKCortistatin8Cortistatin 8GHSRGrowth hormone secretagogue receptorGhrelin receptorneuropeptideCSTSST-RGHS-R1aghrelingastric acid secretion andin vitroto modulate GH release from somatotroph cellInhibitorinhibitorinhibit

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