2. Immunology/Inflammation
  3. COX
  4. COX-1/2-IN-8

COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib (HY-14398).

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COX-1/2-IN-8 Chemical Structure

COX-1/2-IN-8 Chemical Structure

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COX-1/2-IN-8 Related Antibodies

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Description

COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib (HY-14398)[1].

IC50 & Target

COX-2

0.58 ± 0.0 μM (IC50)

COX-1

2.14 ± 0.0 μM (IC50)

In Vivo

COX-1/2-IN-8 (compound 11f) (50 mg/kg, p.o.) shows anti-inflammatory activity in rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

530.68

Formula

C33H30N4OS
SMILES

O=C(C1=CC=CC=C1)CSC2=NN=C(C(N3CC4=C(C=CC=C4)CC3)C5=CC=CC=C5)N2C6=CC=C(C)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-1/2-IN-8 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-1/2-IN-8COXCyclooxygenaseAnti-inflammatoryorally activeInhibitorinhibitorinhibit

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