2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. COX Lipoxygenase
  4. COX-2/5-LOX-IN-3

COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases.

For research use only. We do not sell to patients.

COX-2/5-LOX-IN-3 Chemical Structure

COX-2/5-LOX-IN-3 Chemical Structure

CAS No. : 2481484-51-7

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COX-2/5-LOX-IN-3 Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

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5-LOX 12-LOX 15-LOX

  • Biological Activity

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Description

COX-2/5-LOX-IN-3 (compound 5b) is a potent and dual COX-2/5-LOX inhibitor with IC50 values of 45.73, 5.45 and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. COX-2/5-LOX-IN-3 has the potential for the research of inflammation diseases[1].

IC50 & Target[1]

5-LOX

4.33 μM (IC50)

COX-2

5.45 μM (IC50)

COX-1

45.73 μM (IC50)

In Vivo

COX-2/5-LOX-IN-3 (compound 5b) (p.o.; male Sprague Dawley rats) shows anti-inflammatory activities in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[1]
Dosage: 2.622 X 10-5 mol/kg
Administration: Oral administration
Result: The percentage inhibition of edema (%I) reached 58.77% after 4h.
Molecular Weight

361.85

Formula

C17H16ClN3O2S
CAS No.
SMILES

O=C(NC1=C(C#N)C(C2=CC=C(Cl)C=C2)=CS1)CN3CCOCC3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2/5-LOX-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2/5-LOX-IN-32481484-51-7COXLipoxygenaseCyclooxygenaseLOXanti-inflammatorythiophenesCOX-1/COX-25-LOXInhibitorinhibitorinhibit

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