COX-2-IN-24

Cat. No.: HY-147963: FAQs
Data Sheet Handling Instructions

Molarity Calculator

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC₅₀ value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

For research use only. We do not sell to patients.

COX-2-IN-24 Chemical Structure

CAS No. : 2417995-10-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All COX Isoform Specific Products:

View All Isoforms

COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC₅₀ value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

IC₅₀ & Target

COX-2

0.17 μM (IC₅₀)

In Vivo

COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model^[1].
COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mature male albino rats^[1]
Dosage:	9mg/100g
Administration:	Intraperitoneal injection; 9mg/100g; once an hour; 4 hours
Result:	Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model.

Animal Model:	Mature male albino rats^[1]
Dosage:	9mg/100g
Administration:	Oral gavage; 9mg/100g; once a day; 3 days
Result:	Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.

Molecular Weight

574.51

Formula

C₂₄H₂₄BrN₅O₃S₂

CAS No.

2417995-10-7

SMILES

O=S(C1=CC(C(N2C3=CC=C(Br)C=C3)=NNC2=S)=CC(NCCCC)=C1OC4=CC=CC=C4)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tarek S Ibrahim, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878. [Content Brief]

COX-2-IN-24 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-242417995-10-7COXCyclooxygenaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks