2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-44

COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity.

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COX-2-IN-44 Chemical Structure

COX-2-IN-44 Chemical Structure

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COX-2-IN-44 Related Antibodies

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Description

COX-2-IN-44 is a potent and orally active COX-2 inhibitor with IC50 values of 0.18,1.14 µM for COX-2, COX-1, respectively. COX-2-IN-44 shows anti-inflammatory activity[1].

IC50 & Target[1]

COX-2

0.18 μM (IC50)

COX-1

1.14 μM (IC50)

In Vivo

COX-2-IN-44 (compound 6b) (10 mg/kg; p.o.) shows anti-inflammatory activity in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twenty-five adult albino Wistar rats (paw edema)[1]
Dosage: 10 mg/kg
Administration: P.o.
Result: Showed anti-inflammatory activity and caused a decrease in paw volume over time and scored a percentage edema of 61.62 %, 54.34 %, and 44.64 % at the 1st, 2nd, and 3rd hour, respectively, decreased the PGE2 plasma level by 42.6 %, reduced the level of IL-1β by 32.0 %.
Molecular Weight

441.95

Formula

C27H24ClN3O
SMILES

CC(C=C1)=CC=C1NC(C(CC2=CC=C(Cl)C=C2)=C3)=NN=C3/C=C/C4=CC=C(OC)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-44 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-44COXCyclooxygenaseorally activePGE2IL-1βanti-inflammatoryInhibitorinhibitorinhibit

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HY-161862
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