2. Immunology/Inflammation NF-κB
  3. COX NF-κB NO Synthase
  4. COX-2-IN-48

COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.

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COX-2-IN-48 Chemical Structure

COX-2-IN-48 Chemical Structure

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COX-2-IN-48 Related Antibodies

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All NO Synthase Isoform Specific Products:

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nNOS iNOS eNOS

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Description

COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS[1].

IC50 & Target[1]

Human COX-2

51.7 nM (IC50)

NF-κB p65

 

iNOS

 

Molecular Weight

455.86

Formula

C25H17ClF3NO2
SMILES

FC(C1=C(C2=CC=C(Cl)C=C2)C(C3=CNC4=C3C=CC=C4)C5=C(O1)C=CC(OC)=C5)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-48 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-48COXNF-κBNO SynthaseCyclooxygenaseNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCOX-2analgesicNF-κB p65iNOSInhibitorinhibitorinhibit

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