1. Immunology/Inflammation NF-κB
  2. COX NF-κB NO Synthase
  3. COX-2-IN-48

COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS.

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COX-2-IN-48 Chemical Structure

COX-2-IN-48 Chemical Structure

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Description

COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC50 of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS[1].

IC50 & Target[1]

Human COX-2

51.7 nM (IC50)

NF-κB p65

 

iNOS

 

Molecular Weight

455.86

Formula

C25H17ClF3NO2

SMILES

FC(C1=C(C2=CC=C(Cl)C=C2)C(C3=CNC4=C3C=CC=C4)C5=C(O1)C=CC(OC)=C5)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
COX-2-IN-48
Cat. No.:
HY-168070
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