COX-2/NO-IN-1 

COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC₅₀ of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects^[1].

COX-2/NO-IN-1 (Compound 13b; 2.5-10 μM) exhibits potent activity through dose-dependent inhibiting the production of nitric oxide (NO, IC₅₀ = 3.52 μM), TNF-α and IL-6 (84.1% and 33.6%, respectively), as well as suppressing the expression of iNOS, COX-2 and TLR4 proteins in LPS-stimulated RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In C57BL/6 mice with cisplatin-induced AKI, COX-2/NO-IN-1 (Compound 13b; 15-30 mg/kg; p.o.) improves kidney function, inhibits inflammatory development, and reduces pathological damage of kidney tissues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

257.28

C₁₅H₁₅NO₃

2989882-91-7

C=C(C(C1=CC2=CC=CC=C2N=C1)O)C(OCC)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jiawei Zuo, et al. Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury. Bioorg Chem. 2020 Dec;105:104455.  [Content Brief]