CP-690550A

Cat. No.: HY-123289: FAQs
Data Sheet Handling Instructions

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CP-690550A is an analogue of Tofacitinib (HY-40354). CP-690550A is a dual inhibitor of JAK2 and JAK3.

For research use only. We do not sell to patients.

CP-690550A Chemical Structure

CAS No. : 1243290-37-0

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JAK1 JAK2 JAK3 Tyk2 JAK

Biological Activity
Purity & Documentation
References
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Description

CP-690550A is an analogue of Tofacitinib (HY-40354). CP-690550A is a dual inhibitor of JAK2 and JAK3^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	32 nM Compound: 17d	Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
Sf9	IC₅₀	480 nM Compound: 17d	Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK2 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
Sf9	IC₅₀	840 nM Compound: 17d	Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA Inhibition of GST-tagged human JAK1 catalytic domain expressed in Sf9 cells by ELISA	[PMID: 21105711]
T-cell	IC₅₀	450 nM Compound: 17d	Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay Inhibition of human IL2-dependent T cell blast proliferation assessed as reduction in [3H]thymidine incorporation after 72 hrs post dose IL2 blast assay	[PMID: 21105711]

Molecular Weight

303.36

Formula

C₁₅H₂₁N₅O₂

CAS No.

1243290-37-0

SMILES

CN([C@H]1CN(CC[C@H]1C)C(CO)=O)C2=C3C(NC=C3)=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chrencik JE, et al. Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6. J Mol Biol. 2010 Jul 16;400(3):413-33. [Content Brief]

CP-690550A Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-690550A1243290-37-0JAKJanus kinaseJAK3inflammatorymyeloproliferative diseasesInhibitorinhibitorinhibit

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