2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. CP94253

CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. CP94253 binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, with Kis of 2, 89, 49, 860 and 1600 nM. CP94253 causes satiety, anorexia, weight loss and hyperlocomotion in rats model.

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CP94253 Chemical Structure

CP94253 Chemical Structure

CAS No. : 131084-35-0

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CP94253 Related Antibodies

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Description

CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. CP94253 binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, with Kis of 2, 89, 49, 860 and 1600 nM. CP94253 causes satiety, anorexia, weight loss and hyperlocomotion in rats model[1].

IC50 & Target

5-HT1B Receptor

2 nM (Ki)

5-HT1D Receptor

49 nM (Ki)

5-HT1A Receptor

89 nM (Ki)

5-HT1C Receptor

860 nM (Ki)

5-HT2 Receptor

1600 nM (Ki)

Molecular Weight

257.33

Formula

C15H19N3O
CAS No.
SMILES

CCCOC1=NC2=C(NC=C2C3=CCNCC3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP94253 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP94253131084-35-0CP 94253CP-942535-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptoranorexiasatietyhyperlocomotionselectiveorally activeSprague Dawley ratInhibitorinhibitorinhibit

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