CPF-7 (Synonyms: Caerulein precursor fragment)

Cat. No.: HY-P5291: FAQs
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CPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

CPF-7 Chemical Structure

CAS No. : 103238-06-8

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Description

In Vitro

CPF-7 (50 nM; 7 days) converts PANC-1 exocrine cells into pancreatic endocrine precursor cells^[1].
CPF-7 (3 µM; 20 min) produces the stimulation of insulin release in BRIN-BD11 rat clonal β-cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	PANC1 cells
Concentration:	50 nM
Incubation Time:	7 days (change medium every 24 h)
Result:	Increased Ngn3 (the principal determinant of endocrine precursor cells) expression level.

Immunofluorescence^[2]

Cell Line:	BRIN-BD11 rat clonal β-cells
Concentration:	3 µM
Incubation Time:	20 min
Result:	Stimulated insulin release.

Molecular Weight

2586.00

Formula

C₁₁₈H₁₉₃N₃₃O₃₂

CAS No.

103238-06-8

Sequence

Gly-Phe-Gly-Ser-Phe-Leu-Gly-Lys-Ala-Leu-Lys-Ala-Ala-Leu-Lys-Ile-Gly-Ala-Asn-Ala-Leu-Gly-Gly-Ala-Pro-Gln-Gln

Sequence Shortening

GFGSFLGKALKAALKIGANALGGAPQQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Heydari M, et al. Differentiation of PANC-1 ductal cells to β-like cells via cellular GABA modulation by Magainin and CPF-7 peptides. Biochem Biophys Res Commun. 2022 Feb 1;597:128-133. [Content Brief]

[2]. Srinivasan D, et al. Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents. Biochimie. 2013 Feb;95(2):429-35. [Content Brief]

CPF-7 Related Classifications

Metabolic Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPF-7103238-06-8Caerulein precursor fragmentCPF7CPF 7OthersPANC1 cellsNgn3Snai1type 2 diabetesBRIN-BD11 cellsInhibitorinhibitorinhibit

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