2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. CPN-219

CPN-219, a next-generation hexapeptidic NMUR2 agonist, achieves a dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CPN-219 Chemical Structure

CPN-219 Chemical Structure

CAS No. : 2240202-02-0

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Based on 1 publication(s) in Google Scholar

CPN-219 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

CPN-219, a next-generation hexapeptidic NMUR2 agonist, achieves a dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM[1].

In Vivo

CPN-219 (25-250 µg; intranasal administration) suppresses body weight gain of mice in a dose-dependent manner. In contrast, intraperitoneal injection (250 µg) is ineffective[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddY mice[1].
Dosage: 250, 100, 25 µg/mouse.
Administration: Applied to the nasal cavity; at days 1 and 4
Result: Suppressed body weight gain of mice in a dose-dependent manner.
Molecular Weight

849.08

Formula

C40H72N12O8
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{3-Cyclohexylpropionyl}-Leu-Leu-{Dbu}-Pro-Arg-Asn-NH2
Sequence Shortening

{3-Cyclohexylpropionyl}-LL-{Dbu}-PRN-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 32 mg/mL (37.69 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1777 mL 5.8887 mL 11.7775 mL
5 mM 0.2355 mL 1.1777 mL 2.3555 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    CPN-219 was dissolved in saline[1].

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1777 mL 5.8887 mL 11.7775 mL 29.4436 mL
5 mM 0.2355 mL 1.1777 mL 2.3555 mL 5.8887 mL
10 mM 0.1178 mL 0.5889 mL 1.1777 mL 2.9444 mL
15 mM 0.0785 mL 0.3926 mL 0.7852 mL 1.9629 mL
20 mM 0.0589 mL 0.2944 mL 0.5889 mL 1.4722 mL
25 mM 0.0471 mL 0.2355 mL 0.4711 mL 1.1777 mL
30 mM 0.0393 mL 0.1963 mL 0.3926 mL 0.9815 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CPN-219 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPN-2192240202-02-0CPN219CPN 219Inhibitorinhibitorinhibit

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HY-P3030
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