2. Peptides
  3. Peptide and Derivatives
  4. CPP12 TFA

CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. CPP12 TFA binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. CPP12 TFA can be used for intracellular delivery of drugs and chemical probes.

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CPP12 TFA Chemical Structure

CPP12 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 240 In-stock
5 mg USD 600 In-stock
10 mg USD 900 In-stock
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100 mg   Get quote  

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Other Forms of CPP12 TFA:

CPP12 TFA Related Antibodies

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Description

CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. CPP12 TFA binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. CPP12 TFA can be used for intracellular delivery of drugs and chemical probes[1].

Molecular Weight

1700.55

Formula

C68H89F12N21O17
Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (58.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5880 mL 2.9402 mL 5.8805 mL
5 mM 0.1176 mL 0.5880 mL 1.1761 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5880 mL 2.9402 mL 5.8805 mL 14.7011 mL
5 mM 0.1176 mL 0.5880 mL 1.1761 mL 2.9402 mL
10 mM 0.0588 mL 0.2940 mL 0.5880 mL 1.4701 mL
15 mM 0.0392 mL 0.1960 mL 0.3920 mL 0.9801 mL
20 mM 0.0294 mL 0.1470 mL 0.2940 mL 0.7351 mL
25 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5880 mL
30 mM 0.0196 mL 0.0980 mL 0.1960 mL 0.4900 mL
40 mM 0.0147 mL 0.0735 mL 0.1470 mL 0.3675 mL
50 mM 0.0118 mL 0.0588 mL 0.1176 mL 0.2940 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CPP12 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPP12CPP 12CPP-12OthersAmphiphiliccell-penetrating peptidesplasma membrane phospholipidschemical probesdrug deliveryInhibitorinhibitorinhibit

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