2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. CPPG

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.

For research use only. We do not sell to patients.

CPPG Chemical Structure

CPPG Chemical Structure

CAS No. : 183364-82-1

Size Price Stock Quantity
1 mg USD 50 In-stock
5 mg USD 108 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

CPPG Related Antibodies

Top Publications Citing Use of Products

View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

IC50 & Target[1]

group III mGlu receptors

2.2 nM (IC50)

group II mGlu receptors

46.2 nM (IC50)

In Vitro

CPPG ((RS)-CPPG) potently reversed both L-AP4 (IC50=2.2 nM)- and L-CCG-I (IC50=46.2 nM) -mediated inhibition of forskolin-stimulated cyclic AMP accumulation in adult rat cortical slices. CPPG is a potent antagonist against group II/III mGlu receptors in the adult rat cortex and shows moderate selectivity for group III mGlu receptors. Conversely, CPPG has weak effects at group I mGlu receptors in both the neonatal rat cortex and cultured cerebellar granule cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPPG Related Antibodies
Molecular Weight

271.21

Formula

C11H14NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 50 mg/mL (184.36 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6872 mL 18.4359 mL 36.8718 mL
5 mM 0.7374 mL 3.6872 mL 7.3744 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (392 KB)

COA (249 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH 1 mM 3.6872 mL 18.4359 mL 36.8718 mL 92.1795 mL
5 mM 0.7374 mL 3.6872 mL 7.3744 mL 18.4359 mL
10 mM 0.3687 mL 1.8436 mL 3.6872 mL 9.2179 mL
15 mM 0.2458 mL 1.2291 mL 2.4581 mL 6.1453 mL
20 mM 0.1844 mL 0.9218 mL 1.8436 mL 4.6090 mL
25 mM 0.1475 mL 0.7374 mL 1.4749 mL 3.6872 mL
30 mM 0.1229 mL 0.6145 mL 1.2291 mL 3.0726 mL
40 mM 0.0922 mL 0.4609 mL 0.9218 mL 2.3045 mL
50 mM 0.0737 mL 0.3687 mL 0.7374 mL 1.8436 mL
60 mM 0.0615 mL 0.3073 mL 0.6145 mL 1.5363 mL
80 mM 0.0461 mL 0.2304 mL 0.4609 mL 1.1522 mL
100 mM 0.0369 mL 0.1844 mL 0.3687 mL 0.9218 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CPPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPPG183364-82-1(RS)-CPPGmGluRMetabotropic glutamate receptorsratcortexAMPaccumulationselectiveCNScerebralInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CPPG
Cat. No.:
HY-101333
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (392 KB) Français - FR (392 KB) Deutsch - DE (392 KB) Norwegian - NO (392 KB) Español - ES (392 KB) Swedish - SV (392 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.