2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. CPUY201112

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research.

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CPUY201112 Chemical Structure

CPUY201112 Chemical Structure

CAS No. : 1860793-58-3

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Description

CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.76 μM
Compound: 50
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 27933959]
MCF7 IC50
0.62 μM
Compound: 50
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 27933959]
In Vitro

CPUY201112 (0-9 μM, 7 days) reduces the viability of multiple cancer cell lines such as HCT116 colon cells, HepG2 hepatocellular carcinoma and other cancer cells in a dose-dependent manner[1].
CPUY201112 (0-2 μM, 24 h) can induce apoptosis in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPUY201112 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116, HepG2, MCF-7, A549
Concentration: 0-9 μM
Incubation Time: 7 days
Result: Inhibited MCF-7, A549, HCT116 and HepG2 cells with the IC50 values of 0.624, 0.543, 0.763 and 0.342 μM, respectively.

Apoptosis Analysis[1]

Cell Line: MCF-7 and HCT116 cells
Concentration: 0-2 μM
Incubation Time: 24 h
Result: Induced cell cycle arrest in G2/M phase and induced apoptosis in more than 35% of MCF-7 cells.
Induced p53-mediated apoptosis in HCT116 cells.
In Vivo

CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) inhibits tumor growth in the MCF-7 tumor xenograft model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MCF-7 cell[1]
Dosage: 5 mg/kg, 20 mg/kg and 40 mg/kg
Administration: i.p., daily, 3 weeks
Result: Reduced tumor volume by 11.92%, 26.58% and 39.63%, respectively, when using 5 mg/kg, 20 mg/kg and 40 mg/kg.
Significantly induced the expression of Hsp70 and reduced the expression of Akt at 40 mg/kg.
Molecular Weight

357.40

Formula

C19H23N3O4
CAS No.
SMILES

O=C(N1CCC2=NC(OCC)=NC=C2C1)C3=CC(C(C)C)=C(C=C3O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CPUY201112 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPUY2011121860793-58-3CPUY 201112CPUY-201112HSPApoptosisHeat shock proteinsHsp90p53apoptosiscell cyclecancerInhibitorinhibitorinhibit

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