2. Apoptosis Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. Apoptosis c-Met/HGFR mTOR PI3K Akt
  4. CRI9

CRI9 inhibits the c-MET/PI3K/Akt/mTOR pathway, suppressing the growth of liver cancer cells. CRI9 shows strong cytotoxicity against HCC cells, inducing apoptosis.

For research use only. We do not sell to patients.

CRI9 Chemical Structure

CRI9 Chemical Structure

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CRI9 Related Antibodies

Top Publications Citing Use of Products

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mTOR mTORC1 mTORC2

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Akt Akt1 Akt2 Akt3

  • Biological Activity

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Description

CRI9 inhibits the c-MET/PI3K/Akt/mTOR pathway, suppressing the growth of liver cancer cells. CRI9 shows strong cytotoxicity against HCC cells, inducing apoptosis[1].

Molecular Weight

478.46

Formula

C26H18N6O4
SMILES

O=C(C1=CC=CC=C1N/2)C2=C3C(N(CC4=CN(C5=CC([N+]([O-])=O)=CC=C5C)N=N4)C6=C\3C=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CRI9 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRI9CRI 9CRI-9Apoptosisc-Met/HGFRmTORPI3KAktMammalian target of RapamycinPhosphoinositide 3-kinasePKBProtein kinase BAnticancerHCCInhibitorinhibitorinhibit

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