2. Membrane Transporter/Ion Channel Apoptosis
  3. CRM1 Apoptosis
  4. CRM1-IN-2

CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis.

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CRM1-IN-2 Chemical Structure

CRM1-IN-2 Chemical Structure

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CRM1-IN-2 Related Antibodies

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Description

CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis[1].

Molecular Weight

504.70

Formula

C29H48N2O5
SMILES

[H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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CRM1-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRM1-IN-2CRM1ApoptosisChromosomal Maintenance 1Exportin 1XPO1nuclear exportcolorectal cancerHCT116RKOHeLaInhibitorinhibitorinhibit

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