2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Crocin-4

Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities.

For research use only. We do not sell to patients.

Crocin-4 Chemical Structure

Crocin-4 Chemical Structure

CAS No. : 55750-86-2

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Crocin-4 Related Antibodies

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Description

Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities[1][2][3].

In Vitro

Crocin-4 (0.1-1000 μM; 24-72 h) do not compromise cell viability of neuron-like cells[1].
Crocin-4 (1 mM; 72 h) reduces total PSEN1, PSEN1 and PSEN2 complexes, BACE1, APP-C99 and sAPPα, while it increases PSEN1-CTF and PSEN2 in SH-SY5Y-APP cells[1].
Crocin-4 (1 mM; 72 h) suppresses GSK3β and ERK1/2 kinases in PC12-htau cells, and significantly reduces the levels and phosphorylation of tau on the pThr231 and pSer199/Ser202 epitopes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Crocin-4 Related Antibodies

Western Blot Analysis[1]

Cell Line: Differentiated SH-SY5Y-APP cells
Concentration: 1 mM
Incubation Time: 72 hours
Result: Significantly reduced total PSEN1 by 19%, and the PSEN1 and PSEN2 complexes by 81 and 65%, while it increased PSEN1-CTF (26%) and PSEN2 (43%).
The key molecules of the amyloidogenic pathway, BACE1 and APP-C99 were significantly reduced by 20 and 28%, respectively.
The non-amyloidogenic pathway product sAPPα was also reduced, by 44%, while APP-C83 remained unaltered.

Western Blot Analysis[1]

Cell Line: Differentiated PC12-htau cells
Concentration: 1 mM
Incubation Time: 72 hours
Result: Significantly reduced total tau levels (by 32%) and tau phosphorylation (pThr231 and pSer199/Ser202-tau by 22 and 75%, respectively).
Downregulates the active and inactive forms of GSK3β (total GSK3β by 34%, pSer9-GSK3β by 30%) and ERK1/2 (total ERK2 by 37%, pERK1 by 40%, pERK2 by 50%).
In Vivo

Crocin-4 (50 mg/kg; i.p.) is capable of crossing the Blood Brain Barrier (BBB) and build up levels in the mouse brain[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

504.57

Formula

C27H36O9
CAS No.
SMILES

COC(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Crocin-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crocin-455750-86-2Crocin4Crocin 4Reactive Oxygen SpeciescarotenoidsaffronantioxidantAβAlzheimer'santi-inflammatorytumorInhibitorinhibitorinhibit

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