2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Crotamine TFA

Crotamine TFA is a Na+ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom.

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Crotamine TFA Chemical Structure

Crotamine TFA Chemical Structure

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10 mg USD 3150 In-stock
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Other Forms of Crotamine TFA:

Crotamine TFA Related Antibodies

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Description

Crotamine TFA is a Na+ channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom[1][2].

Molecular Weight

4883.73 (free base)

Formula

C214H326N64O54S7.xC2HF3O2
Appearance

Solid

Sequence

Tyr-Lys-Gln-Cys-His-Lys-Lys-Gly-Gly-His-Cys-Phe-Pro-Lys-Glu-Lys-Ile-Cys-Leu-Pro-Pro-Ser-Ser-Asp-Phe-Gly-Lys-Met-Asp-Cys-Arg-Trp-Arg-Trp-Lys-Cys-Cys-Lys-Lys-Gly-Ser-Gly (Disulfide bonds：Cys4-Cys36, Cys11-Cys30, Cys18-Cys37)
Sequence Shortening

YKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSG (Disulfide bonds：Cys4-Cys36, Cys11-Cys30, Cys18-Cys37)
SMILES

O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H]1NC2=O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@@H](CC4=CNC=N4)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)NC9=O)C(N[C@@H](CC%10=CC=CC=C%10)C(N%11[C@@H](CCC%11)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(NCC(O)=O)=O)=O)=O)=O)=O)NC1=O)C(N[C@@H](CC(C)C)C(N%12[C@@H](CCC%12)C(N%13[C@@H](CCC%13)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%14=CC=CC=C%14)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@H]9CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%15=CC=C(C=C%15)O)N.OC(C(F)(F)F)=O.[x]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL

*"≥" means soluble, but saturation unknown.

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
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Crotamine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CrotamineSodium ChannelNa channelsNa+ channelsNa+ channelvenomanalgesictoxinlipid membraneInhibitorinhibitorinhibit

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