2. GPCR/G Protein
  3. GCGR
  4. Crotedumab

Crotedumab  (Synonyms: REGN1193; Anti-GCGR Reference Antibody (crotedumab))

Cat. No.: HY-P99357 Purity: 96.61%
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Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.

For research use only. We do not sell to patients.

CAS No. : 1452387-69-7

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
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Crotedumab Related Antibodies

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Description

Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes[1][2].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Human
IC50 & Target

KD: 0.1 nM[2]
In Vitro

Crotedumab binds to GCGR from multiple species (mouse, rat, monkey, and humans) with high affinity (KD=0.03 nM-0.39 nM)[2].
Crotedumab inhibits Glucagon-induced signaling through GCGR with IC50s of 0.65, 3.2, 0.94 and 1.0 nM in HEK293 cells transfected with GCGR from human, monkey, mouse, and rat, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Crotedumab Related Antibodies
In Vivo

Crotedumab (3-30 mg/kg; s.c. once weekly for 4 weeks) reduces blood glucose and body weight and induces reversible hyperglucagonemia and α-cell hyperplasia in DIO C57BL/6 mice[2].
Crotedumab (10 mg/kg; a single s.c.) markedly decreases blood glucose for 18 days in diabetic ob/ob mice[2].
REGN1193 (20 mg/kg; a single i.v.) produces a robust reduction in overnight-fasted blood glucose in both the conscious and anesthetized state of diabetic cynomolgus monkeys as well as in blood glucose measured 1 hour after feeding[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-induced obese (DIO) male C57BL/6NTac mice were maintained on high-fat diet[2]
Dosage: 3, 10, 30 mg/kg
Administration: S.c. injection once weekly for 4 weeks
Result: Markedly reduced blood glucose throughout the dosing period.
Reversibly decreased body weight during the dosing period.
Dose- and time-dependently increased glucagon and GLP-1.
Reversibly increased α-cell area.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Crotedumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Crotedumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crotedumab1452387-69-7REGN1193 Anti-GCGR Reference Antibody (crotedumab)REGN 1193REGN-1193GCGRGlucagon ReceptorInhibitorinhibitorinhibit

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