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  4. Cryogenine

Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

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Cryogenine Chemical Structure

Cryogenine Chemical Structure

CAS No. : 10308-13-1

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Cryogenine Related Antibodies

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Description

Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC50=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

Molecular Weight

435.51

Formula

C26H29NO5
CAS No.
SMILES

COC(C=C([C@@]1([H])N(CCCC2)[C@@]2([H])C[C@@](OC3=O)([H])C1)C(C(C=C(/C=C\3)C=C4)=C4O)=C5)=C5OC
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Room temperature in continental US; may vary elsewhere.
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Cryogenine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cryogenine10308-13-1NSC 272693NSC272693NSC-272693OthersInhibitorinhibitorinhibit

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