2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. HDAC PPAR Apoptosis
  4. CS4

CS4 is a selective HDAC inhibitor with the IC50 values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes α-tubulin and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro.

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CS4 Chemical Structure

CS4 Chemical Structure

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CS4 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

View All PPAR Isoform Specific Products:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

CS4 is a selective HDAC inhibitor with the IC50 values of 38 nM, 12 nM, 5.8 μM, 19 μM and 61 μM against of HDAC1, HDAC6, HDAC8, HDAC4 and HDAC11, respectively. CS4 promotes α-tubulin and histone 3 acetylation. CS4 activates PPARγ and blocks glycolysis. CS4 induces cell cycle arrest at G2 phase and apoptosis, and shows anticancer effect both in vivo and in vitro[1].

Molecular Weight

288.34

Formula

C16H20N2O3
SMILES

ONC(CCCCCCOC1=CC=CC2=C1N=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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CS4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS4CS 4CS-4HDACPPARApoptosisHistone deacetylasesPeroxisome proliferator-activated receptorsA375SK-MEL-5MRC-5antimelanomaInhibitorinhibitorinhibit

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