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  4. CWHM-1552

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.

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CWHM-1552 Chemical Structure

CWHM-1552 Chemical Structure

CAS No. : 2368253-58-9

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Based on 1 publication(s) in Google Scholar

CWHM-1552 Related Antibodies

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Description

CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively[1].

IC50 & Target

IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)[1]
In Vivo

CWHM-1552 (Compound (-)-32a) (orally; 3-30 mg/kg/day for 4 days) inhibits parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day[1].
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. chabaudi ASS infected Mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Orally; daily for 4 days
Result: Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
Animal Model: Male KM mice[1]
Dosage: 2 mg/kg
Administration: I.v. administration; daily
Result: Had respectable half-lives (2.7 h) and low clearance in mice.
Molecular Weight

387.47

Formula

C22H27F2N3O
CAS No.
SMILES

CN(C)C1=CC=C(CC(N[C@@H]2CNC[C@H]2C3=CC=C(C(F)(C)F)C=C3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CWHM-1552 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CWHM-15522368253-58-9CWHM1552CWHM 1552ParasiteInhibitorinhibitorinhibit

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CWHM-1552
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HY-128354
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