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  4. CXCL9(74-103)

CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity.

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CXCL9(74-103) Chemical Structure

CXCL9(74-103) Chemical Structure

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Description

CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity[1].

In Vitro

CXCL9(74-103) (0.3-3 μM; 3-4 days) reduces growth factor-induced endothelial cell proliferation, migration, (0.3-3 μM; 15 min) adhesion, and spheroid sprouting in HMVECs. CXCL9(74-103) (0.3-3 μM; 24 h) is not cytotoxic in HMVECs[1].
CXCL9(74-103) (3 μM) interferes with growth factor signaling by reducing VEGF165 binding to HS and directly binding to FGF-2, and relies on cell surface HS binding to endothelial cells to exert its anti-angiogenic activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CXCL9(74-103) (subcutaneously implanted osmotic pump containing 400 µg/100 µL) significantly reduces FGF-2-induced Matrigel plug angiogenesis in C57BL/6 mice. CXCL9(74-103) (administered as 10 μL drops of 100 μg/mL, once daily for 4 days) reduces pathological blood vessel growth in the corneal burn model of C57BL/6 mice. CXCL9(74-103) (subcutaneously implanted osmotic pump containing 800 µg/100 µL, delivering a continuous dose over the course of two weeks) attenuates tumor angiogenesis in MDA-MB-231 breast cancer SCID mice. Additionally, CXCL9(74-103) also reduces vascular leakage in the retina of diabetic rats, demonstrating its anti-angiogenic effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3661.40

Formula

C158H295N59O40

Sequence

Lys-Lys-Lys-Gln-Lys-Asn-Gly-Lys-Lys-His-Gln-Lys-Lys-Lys-Val-Leu-Lys-Val-Arg-Lys-Ser-Gln-Arg-Ser-Arg-Gln-Lys-Lys-Thr-Thr

Sequence Shortening

KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CXCL9(74-103)
Cat. No.:
HY-P10301
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