Cyclizine lactate

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Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness.

For research use only. We do not sell to patients.

Cyclizine lactate Chemical Structure

CAS No. : 5897-19-8

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Other In-stock Forms of Cyclizine lactate:

Cyclizine

Other Forms of Cyclizine lactate:

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
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Description

Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness^[1]^[2]^[3].

IC₅₀ & Target^[1]

H₁ Receptor

In Vitro

Cyclizine (100 μM) lactate significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants^[1].
Cyclizine lactate inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC₅₀ of 5.42 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cyclizine (1-10 mg/kg) lactate enhances locomotor activity of mice in a dose-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

356.46

Formula

C₂₁H₂₈N₂O₃

CAS No.

5897-19-8

SMILES

CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.OC(C)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. [Content Brief]

[2]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7. [Content Brief]

[3]. Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6. [Content Brief]