2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. Cyclo(CRLLIF)

Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively.

For research use only. We do not sell to patients.

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Cyclo(CRLLIF) Chemical Structure

Cyclo(CRLLIF) Chemical Structure

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Cyclo(CRLLIF) Related Antibodies

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HIF-1α HIF

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Description

Cyclo CRLLIF is a dual inhibitor for hypoxia inducible factor (HIF) 1 and 2, which disrupts the interaction of both HIF1-α and HIF2-α with HIF1-β, with affinity for HIF1-α and HIF2-α PAS-B domains KD of 14.5 and 10.2 μM, respectively[1].

IC50 & Target

HIF-2α

10.2 μM (Kd)

HIF-1α

14.5 μM (Kd)

Molecular Weight

745.98

Formula

C36H59N9O6S
Sequence

Cyclo(Cys-Arg-Leu-Leu-Ile-Phe)
Sequence Shortening

Cyclo(CRLLIF)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cyclo(CRLLIF) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(CRLLIF)HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHT-REx-293786-OMCF-7Inhibitorinhibitorinhibit

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