Cyclooctyne-O-amido-PEG4-PFP ester

Cat. No.: HY-133576: FAQs
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Cyclooctyne-O-amido-PEG4-PFP ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Cyclooctyne-O-amido-PEG4-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Cyclooctyne-O-amido-PEG4-PFP ester Chemical Structure

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Description	Cyclooctyne-O-amido-PEG4-PFP ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Cyclooctyne-O-amido-PEG4-PFP ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cyclooctyne-O-amido-PEG4-PFP ester Related Antibodies
Molecular Weight	595.55
Formula	C₂₇H₃₄F₅NO₈
SMILES	O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCNC(COC2C#CCCCCC2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (262 KB) Handling Instructions (2659 KB)
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]