2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation
  3. Complement System Antibiotic Phosphatase
  4. Cyclosporin A-d4

Cyclosporin A-d4  (Synonyms: Cyclosporine A-d4; Ciclosporin A-d4; CsA-d4)

Cat. No.: HY-B0579S Purity: 99.20%
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Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

For research use only. We do not sell to patients.

Cyclosporin A-d<sub>4</sub> Chemical Structure

Cyclosporin A-d4 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Cyclosporin A-d4:

Cyclosporin A-d4 Related Antibodies

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Description

Cyclosporin A-d4 is the deuterium labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 ad

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclosporin A-d4 Related Antibodies
Molecular Weight

1206.64

Formula

C62H107D4N11O12
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](C/C=C([2H])/C([2H])([2H])[2H])[C@H]([C@]1([H])N(C([C@@H](N(C([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C)C(C)C)=O)C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (51.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 50 mg/mL (41.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8287 mL 4.1437 mL 8.2875 mL
5 mM 0.1657 mL 0.8287 mL 1.6575 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 0.8287 mL 4.1437 mL 8.2875 mL 20.7187 mL
5 mM 0.1657 mL 0.8287 mL 1.6575 mL 4.1437 mL
10 mM 0.0829 mL 0.4144 mL 0.8287 mL 2.0719 mL
15 mM 0.0552 mL 0.2762 mL 0.5525 mL 1.3812 mL
20 mM 0.0414 mL 0.2072 mL 0.4144 mL 1.0359 mL
25 mM 0.0331 mL 0.1657 mL 0.3315 mL 0.8287 mL
30 mM 0.0276 mL 0.1381 mL 0.2762 mL 0.6906 mL
40 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.5180 mL
DMSO 50 mM 0.0166 mL 0.0829 mL 0.1657 mL 0.4144 mL
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Cyclosporin A-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclosporin A-d4Cyclosporine A-d4Ciclosporin A-d4CsA-d4Complement SystemAntibioticPhosphataseInhibitorinhibitorinhibit

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